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KMID : 0605720060120020140
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Journal of the Korean Society of Biological Therapies in Psychiatry
2006 Volume.12 No. 2 p.140 ~ p.145
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Association Study of an Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism in Korean and Han Chinese Schizophrenics
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Lee Seo-Kyong
Kim Jong-Woo
Yim Sung-Vin
Song Ji-Young
Chung Joo-Ho
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Abstract
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Objective：The purpose of this study was to investigate the association between Insertion/Deletion(I/D) polymorphism of Angiotensin-converting enzyme(ACE) gene and schizophrenia in Korean and Han Chinese population.
Method：We examined the frequency of a polymophism characterized by the insertion of a 287bp in intron 16 of the ACE gene(located on chromosome 17q23). A sample of 153 Korean schizophrenics, 154 Korean healthy controls, 82 Han Chinese schizophrenics and 88 Han Chinese healthy controls were genotyped by size-analysis of polymerase chain reaction products.
Results：There was significant difference in genotype frequencies and allelic frequencies of ACE I/D polymorphism between Korean schizophrenics and controls. There was no difference in genotype frequencies and allelic frequencies of ACE I/D polymorphism between Han Chinese schizophrenics and controls. There was significant difference in genotype frequencies and allelic frequencies of ACE I/D polymorphism between the Korean and Han Chinese controls.
Conclusion：The present study reveals significant association of ACE gene I/D polymorphism in Korean schizophrenics. And there was ethnic diffence between the Korean and Han Chinese polulation.
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KEYWORD
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Schizophrenia, Angiotensin converting enzyme gene, Insertion/Deletion polymorphism, Korean, Han chinese
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